IL27 (center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot: 2 - 4 µg/ml.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide - KLH conjugated corresponding to 14 amino acids from near the center of Human IL27
Specificity	This antibody recognizes Interleukin-27 (IL27) near center.
Isotype	IgG
Formulation	PBS containing 0.02% Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	interleukin 27
Database Link	Entrez Gene 246778 Human UniProt ID Q8NEV9
Background	IL27 is a recently discovered member of the IL6/IL12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL12 p35-related protein termed p28. IL27 is produced after activation by antigen-presenting cells and induces proliferation of naive but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL27 is involved in the regulation of immune processes.
Synonyms	IL-27 subunit alpha, IL27-A, p28, IL30, IL-30, Interleukin-30
Reference Data

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