VAP1 (AOC3) (712-724) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC
Recommend Dilution	ELISA: 1/64000. Immunohistochemistry on Paraffin Sections: 3.75 µg/ml.
Reactivity	Human, Mouse, Rat, Hamster
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide from an internal region of human AOC3
Specificity	This antibody reacts to Copper Amine Oxidase (AOC3) at aa 712-724.
Formulation	Tris saline buffer, pH 7.3, 0.5% BSA, 0.02% sodium azide State: Aff - Purified State: Liquid purified Ig
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	amine oxidase, copper containing 3
Database Link	Entrez Gene 8639 Human UniProt ID Q16853
Background	VAP1, upregulated in response to inflammation, is a cell adhesion protein that participates in lymphocyte recirculation, by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells, in an L selectin independent fashion. VAP1 also displays a monoamine oxidase activity, catalyzing the deamination of methylamine to produce formaldehyde. Upregulation of VAP1 has been reported in Alzheimer's disease, where increased levels of formaldehyde are responsible for b amyloid cross linkage and plaque formation, significantly contributing to the pathogenesis of this disease.
Synonyms	HPAO
Reference Data

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