Plakophilin 1 (PKP1) Guinea Pig Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	Immunofluorescence Microscopy on Frozen Sections: 1/100 (After paraformaldehyde fixation). Immunobloting (Western Blot): 1/1000. Immunohistochemistry on Frozen and Paraffin Sections. Incubation Time: 1h at RT, extended with Paraffin Sections.
Reactivity	Bovine, Human, Mouse, Xenopus
Host	Guinea Pig
Clonality	Polyclonal
Immunogen	Human recombinant Plakophilin 1.
Specificity	PP1 antiserum shows distinct suprabasal staining of stratified epithelia, localizing Plakophilin 1 in desmosomal plaques and in the nucleus. In Western blot analysis the antiserum reacts specifically with the Plakophilin 1a and 1b polypeptides.
Formulation	State: Serum State: Liquid stabilized antierum Preservative: 0.09% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	plakophilin 1
Database Link	Entrez Gene 5317 Human UniProt ID Q13835
Background	Plays a role in formation of desmosomal plaques and is found in desmosomes of most simple and stratified epithelia. Not found in cell types that have non-epithelial desmosomes. Absent in fibroblasts and other connective tissue types, including sarcomas.
Synonyms	Plakophilin-1, Band 6 protein, B6P
Reference Data
Protein Families	Druggable Genome

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