ATF6 (Center) Rabbit Polyclonal Antibody

CAT#: AP17892PU-N

ATF6 (Center) rabbit polyclonal antibody, Aff - Purified



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CNY 6,314.00


货期*
5周

规格
    • 400 ul

Product images

Specifications

Product Data
Applications IHC, WB
Recommend Dilution ELISA: 1/1,000.
Western blotting: 1/100-1/500.
Immunohistochemistry: 1/50-1/100.
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen KLH conjugated synthetic peptide between 356~386 amino acids from the Center region of Human ATF6.
Specificity This antibody recognizes ATF6.
Formulation PBS with 0.09% (W/V) Sodium Azide as preservative.
State: Aff - Purified
State: Liquid purified IgG fraction.
Concentration lot specific
Purification Affinity Chromatography on Protein A.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name activating transcription factor 6
Background ATF6 is a transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. It binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. ATF6 could also be involved in activation of transcription by the serum response factor. ATF6 exists as a homodimer and heterodimer with ATF6 beta. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC). It also interacts with the transcription factors GTF2I, YY1 and SRF. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. The basic domain of ATF6 functions as a nuclear localization signal and the basic leucine zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE. During the unfolded protein response an approximately 50 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site 1 and site 2 proteases. ATF6 is N glycosylated, phosphorylated in vitro by MAPK14/P38MAPK and belongs to the bZIP family.
Synonyms ATF-6, Activating transcription factor 6 alpha
Note Calculated MW: 74585 Da
Reference Data
Protein Families Transcription Factors
Protein Pathways Alzheimer's disease
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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