PXR (NR1I2) (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IF, IHC, WB
Recommend Dilution	ELISA: 1/1,000. Western blotting: 1/1000. Immunohistochemistry: 1/50 - 1/100. Flow Cytometry: 1/10 - 1/50 Immunoflourescence: 1/10 - 1/50
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 100-127 aa selected from the Center region of human NR1I2
Specificity	This antibody reacts to NR1I2.
Formulation	PBS with 0.09% (W/V) sodium azide State: Liquid purified Ig
Concentration	lot specific
Purification	Affinity chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	49762 Da.
Gene Name	nuclear receptor subfamily 1 group I member 2
Database Link	Entrez Gene 8856 Human UniProt ID O75469
Background	NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. This protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin.
Synonyms	PXR
Reference Data
Protein Families	Druggable Genome, Nuclear Hormone Receptor, Transcription Factors

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