LIS1 (PAFAH1B1) (397-410) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/32000. Immunohistochemistry on Paraffin Sections: 3.75 µg/ml. Western Blot: 1 - 3 µg/ml.
Reactivity	Bovine, Canine, Human, Mouse, Porcine, Rat, Bat, Chicken, Equine, Hamster, Monkey, Rabbit, Xenopus, Zebrafish
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide from (C-term) of the protein sequence according to NP_000421
Specificity	This antibody detects PAFAH1B1 / LIS1 at aa 397-410.
Formulation	Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide State: Aff - Purified State: Liquid Ig fracttion
Concentration	lot specific
Purification	Immunoaffinity chromatography
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	platelet activating factor acetylhydrolase 1b regulatory subunit 1
Database Link	Entrez Gene 18472 MouseEntrez Gene 83572 RatEntrez Gene 5048 Human UniProt ID P43034
Background	PAFAH1B1 was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. PAFAH1B1 encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum.
Synonyms	PAF-AH alpha, PAFAH alpha, PAFAHA, Lissencephaly-1 protein, LIS-1, MDCR, MDS
Reference Data
Protein Pathways	Ether lipid metabolism, Metabolic pathways

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