GAD65 (GAD2) (515-528) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/32000. Immunohistochemistry on Paraffin Sections: 2.5 µg/ml. Western Blot: 1/32000, 0.1 - 0.3 µg/ml.
Reactivity	Human, Monkey, Mouse
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic peptide from an internal region of human GAD2
Specificity	This antibody detects GAD2 / GAD65 (Internal).
Formulation	Tris saline buffer, pH 7.3, 0.5% BSA, 0.02% sodium azide State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Immunoaffinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	glutamate decarboxylase 2
Database Link	Entrez Gene 14417 MouseEntrez Gene 613029 MonkeyEntrez Gene 2572 Human UniProt ID Q05329
Background	GAD65 is one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome.
Synonyms	GAD-2, GAD-65, Glutamate decarboxylase 2
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Butanoate metabolism, Metabolic pathways, Taurine and hypotaurine metabolism, Type I diabetes mellitus

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.