TLR3 (514-657) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	Immunocytochemistry. Immunofluorescence: 1/100 - 1/200. Immunohistochemistry on Paraffin Sections: 10 µg/ml. Western Blot: 1/1000 - 1/10000.
Reactivity	Bovine, Feline, Guinea Pig, Human, Monkey, Mouse, Porcine, Rabbit, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	TLR3 antibody was raised against recombinant protein fragment containing a sequence corresponding to a region within amino acids 514 and 657 of TLR3.
Specificity	This antibody reacts to Toll-like Receptor 3 (TLR3) at aa 514-657.
Formulation	0.1 M Tris-glycine, pH 7.0 containing 10% Glycerol and 0.01% Thimerosal State: Aff - Purified State: Liquid purfied Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	toll like receptor 3
Database Link	Entrez Gene 142980 MouseEntrez Gene 364594 RatEntrez Gene 7098 Human UniProt ID O15455
Background	TLR3 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.
Synonyms	Toll-like receptor 3
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Toll-like receptor signaling pathway

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