IL1 Receptor II (IL1R2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA
Recommend Dilution	Immunoassays.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Specificity	The antibody reacts specificly with Human Interleukin (IL-1)RII.  Other species not tested.
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Protein A Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted  at 2-8°C.
Gene Name	interleukin 1 receptor type 2
Database Link	Entrez Gene 7850 Human UniProt ID P27930
Background	The IL-1 system includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1RI and IL-1RII) and the IL-1 receptor accessory protein. The IL-1RII is part of the antagonistic IL-1 mechanism. It is also known as decoy receptor and is a non signalling molecule which functions by capturing IL-1 and preventing it from interacting with the signalling IL-1RI. The decoy IL-1RII can after binding to IL-1 also recruit the IL-1 receptor accessory protein and thus inhibit by coreceptor competition. Further a soluble form of IL-1RII exists which is shed, a process in which matrix metalloproteases have been found to play a role, by various cells including monocytes, polymorphonuclear cells, B cells and fibroblasts.
Synonyms	Interleukin-1 receptor type II, IL-1R-2, IL-1R-beta, CDw121b, IL1RB
Reference Data

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