ITIH4 (890-903) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	Peptide ELISA: Detection Limit: 1/16000. Western Blot: 0.03-0.1 µg/ml. In Human Placenta lysates, a band of ~150kDa is detected corresponding to the glycosylated form. Immunohistochemistry on Paraffin Sections.
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence from the C Terminus of the protein sequence according to NP_002209.2 and NP_001159921.1.
Specificity	This antibody is expected to recognize both reported isoforms (NP_002209.2, NP_001159921.1).
Formulation	Tris saline, pH~7.3 with 0.02% Sodium Azide and 0.5% BSA State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	inter-alpha-trypsin inhibitor heavy chain family member 4
Database Link	Entrez Gene 3700 Human UniProt ID Q14624
Background	The inter-a-trypsin inhibitor (ITI, IaI) family, a typical and classical example for protein-glycosaminoglycanprotein (PGP) complexes, occurs constitutively in plasma at relatively high concentrations and is a result of alternate combinations of three kinds of heavy chains with a common light chain, the bikunin proteoglycan. Bikunin has two proteinase inhibitor domains and belongs to the Kunitz-type protease inhibitor family; it displays an inhibitory activity against trypsin, leukocyte elastase and plasmin. The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid and this binding promotes the stability of the extra-cellular matrix. The ITI protein family is suspected of playing a key role in the extra-cellular matrix biology.
Synonyms	ITI heavy chain H4, IHRP, ITIHL1, PK120, ITI-HC4, Gp120
Note	Calculated Molecular Weight: 103kDa (NP_002209.2).
Reference Data

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