ACK1 (TNK2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/16000. Immunohistochemistry on Paraffin Sections: 1.25 µg/ml. Western Blot: 1/500.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide. Epitope: Amino acids 278-289
Specificity	Recognizes TNK2 / ACK1
Isotype	IgG
Formulation	PBS, pH 7.4 containing 0.05% Sodium Azide as preservative State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	tyrosine kinase non receptor 2
Database Link	Entrez Gene 51789 MouseEntrez Gene 303882 RatEntrez Gene 10188 Human UniProt ID Q07912
Background	ACK encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation pathway.
Synonyms	ACK; ACK-1; ACK1; FLJ44758; FLJ45547; p21cdc42Hs
Reference Data
Protein Families	Druggable Genome, Protein Kinase

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