ETS1 (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IF, WB
Recommend Dilution	ELISA: 1/1000. Western Blot: 1/100-1/500.  Flow Cytometry: 1/10-1/50.  Immunofluorescence: 1/10-1/50.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 46-74 amino acids from the N-terminal region of Human ETS1
Specificity	This antibody recognizes Human ETS1 (N-term).
Formulation	PBS containing 0.09% (W/V) Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	ETS proto-oncogene 1, transcription factor
Database Link	Entrez Gene 2113 Human UniProt ID P14921
Background	ETS transcriptions factors, such as ETS1, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes (summary by Dwyer et al., 2007 [PubMed 17986575]).
Synonyms	Protein C-ets-1, EWSR2, p54
Note	Molecular Weight: 50408 Da
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Dorso-ventral axis formation, Pathways in cancer, Renal cell carcinoma

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