PDE1B (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	ELISA:  1/1000.  Western Blot: 1/1000.  Immunohistochemistry on Paraffin Sections: 1/10-1/50.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 473-500 amino acids from the C-terminal region of Human PDE1B
Specificity	This antibody recognizes Human and Mouse PDE1B (C-term).
Formulation	PBS containing 0.09% (W/V) Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein A column, followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	phosphodiesterase 1B
Database Link	Entrez Gene 18574 MouseEntrez Gene 5153 Human UniProt ID Q01064
Background	Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1B, are calmodulin (see MIM 114180)-dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex (Repaske et al., 1992 [PubMed 1326532]).
Synonyms	Phosphodiesterase 1B, Phosphodiesterase-1B calmodulin-dependent, Cam-PDE 1B, PDE1B1, PDES1B
Note	Molecular Weight: 61380 Da
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Calcium signaling pathway, Progesterone-mediated oocyte maturation, Purine metabolism

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