RHEB (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western Blot: 1/1000.  Immunohistochemistry on Paraffin Sections: 1/50-1/100.
Reactivity	Bovine, Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 104-134 amino acids from the C-terminal region of Human RHEB.
Formulation	PBS State: Purified State: Liquid purified Ig fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Purification	Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	Ras homolog enriched in brain
Database Link	Entrez Gene 19744 MouseEntrez Gene 26954 RatEntrez Gene 6009 Human UniProt ID Q15382
Background	This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22
Synonyms	RHEB2
Note	Molecular Weight: 20497 Da
Reference Data
Protein Pathways	Insulin signaling pathway, mTOR signaling pathway

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