CACNA1B (alpha-1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western Blot: 1/500-1/2000. Immunohistochemistry: 1/100-1/500.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from N-terminal domain of CACNA1B protein
Specificity	Reacts with Human 262 kDa CACNA1B protein.
Formulation	0.1M Tris, 0.1M Glycine and 2% Sucrose State: Purified State: Lyophilized powder Preservative: None
Reconstitution Method	Restore in distilled water.
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store lyophilized antibody at -20°C Store reconstituted antibody at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	calcium voltage-gated channel subunit alpha1 B
Database Link	Entrez Gene 774 Human UniProt ID Q00975
Background	Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1b gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (hva) group and are blocked by omega-conotoxin-GVIA (omega-ctx-GVIA) and by omegaagatoxin-IIIA (omega-aga-IIIA). They are however insensitive to dihydropyridines (dhp), and omega-agatoxin-IVA (omegaaga-IVA). Calcium channels containing alpha-1b subunit may play a role in directed migration of immature neurons.
Synonyms	CACH5, CACNL1A5, Cav2.2, Brain calcium channel III
Reference Data

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