Semaphorin 7a (SEMA7A) Mouse Monoclonal Antibody [Clone ID: MEM-150]

Specifications

Product Data
Clone Name	MEM-150
Applications	FC, IP, WB
Recommend Dilution	Flow Cytometry: 4 µg/ml. Immunoprecipitation. Western Blot under non reducing conditions.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	HPB-ALL human T cell line
Specificity	The antibody reacts with CD108 (JMH blood group antigen), a 80 kDa GPI-anchored glycoprotein expressed on various cell types including erythrocytes, lymphoblasts; at low levels it is present on circulating lymphocytes.
Isotype	IgM
Formulation	Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 State: Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Ion exchange chromatography; purity: > 95% (by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	semaphorin 7A (John Milton Hagen blood group)
Database Link	Entrez Gene 8482 Human UniProt ID O75326
Background	CD108 (Sema7A) is a GPI-anchored semaphorin family member, which enhances central and peripheral axonal growth and is required for proper axon track formation during ebryogenesis. CD108 also regulates osteoclast differentiation and pre-osteoblastic cell migration, and in immune system affects cell proliferation, chemotaxis and cytokine release. On erythrocytes CD108 defines the JMH (John-Milton-Hagen) human blood group. CD108 signalizes through its receptors plexin C1 and b1 integrins.
Synonyms	Semaphorin-7A, SEMAL, Semaphorin-L, Semaphorin-K1
Reference Data

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