Endothelin 1 (EDN1) Rat Monoclonal Antibody [Clone ID: 3G10]

Specifications

Product Data
Clone Name	3G10
Applications	IHC, R
Recommend Dilution	RIA / IRMA. Immunohistochemistry on frozen sections: Frozen sections processed with dry acetone are recommended. Paraformaldehyde is not recommended as it destroys the epitope.
Reactivity	Human
Host	Rat
Clonality	Monoclonal
Immunogen	Synthetic human endothelin-C terminal fragment, conjugated to BSA
Specificity	Reacts with the C-terminal of endothelins 1, 2 and 3. 3G10 does not react with the endothelin precursor molecule, big endothelin.
Isotype	IgG2b
Formulation	PBS, containing 0.09% sodium azide State: Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Protein G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	endothelin 1
Database Link	Entrez Gene 1906 Human UniProt ID P05305
Background	Endothelins are potent vasoconstrictors and critical components in the progression of pulmonary arterial hypertension a devastating and rapidly progressive condition that leads to right ventricular strain and dysfunction.
Synonyms	ET-3, Preproendothelin-3, PPET3, Preproendothelin-1, Big endothelin-1, Endothelin1, PPET1, EDN1, EDN2, Endothelin-2, ET-2, Preproendothelin-2, PPET2
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Melanogenesis

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