Apolipoprotein A I (APOA1) Mouse Monoclonal Antibody [Clone ID: 1404]

Specifications

Product Data
Clone Name	1404
Applications	ELISA, R
Recommend Dilution	Competeitive RIA. ELISA.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified human plasma Apo A-I
Specificity	Hihgly specific for APO A-I, no cross reactivity with APO A-II or Apo B.
Isotype	IgG1
Formulation	0.015 M PBS, 0.15 M NaCl, pH 7.2 with 0.09 % Sodium Azide as preservative State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	DEAE-chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	apolipoprotein A1
Database Link	Entrez Gene 335 Human UniProt ID P02647
Background	Apolipoprotein A I promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A I is the major protein component of high density lipoprotein (HDL) in the plasma. Synthesized in the liver and small intestine, it consists of two identical chains of 77 amino acids; an 18 amino acid signal peptide is removed co-translationally and a 6 amino acid propeptide is cleaved post-translationally. Apolipoprotein A I is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. Defects in the Apolipoprotein A I gene are associated with HDL deficiency and Tangier disease. The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I. The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic vascular diseases.
Synonyms	APOA1, ApoA-I, Apo-AI, ApoAI
Reference Data

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