CD42b / GPIbA Mouse Monoclonal Antibody [Clone ID: SZ2]

Specifications

Product Data
Clone Name	SZ2
Applications	FC, FN, IHC
Recommend Dilution	Studies of platelet functions. Only suitable on frozen sections or cell smears. May be used in Western blot. Fluorescence Microscopy or Flow Cytometry: 2 µg/5x10e6 platelets/test. Immunohistochemistry: Working dilution 1:50 to 1:100.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human washed platelets.
Specificity	The molecular weight of the recognized antigen is 170 kDa. Reacts with Glycoprotein Ib on Megakaryocytes and platelets. Inhibits the Ristocetin-dependent binding of Von Willebrand factor to platelets and Ristocetin induced platelet agglutination. Inhibits platelet aggregation induced by Type I Collagen and platelet activating factor (PAF). Immunoprecipitates the components of Glycoprotein Ib complex.
Formulation	PBS containing 1 mg/ml BSA without preservatives. State: Azide Free State: Lyophilized purified Ig fraction.
Reconstitution Method	Restore with 1 ml distilled water.
Concentration	lot specific
Purification	Protein A chromatography.
Conjugation	Unconjugated
Storage Condition	Store the reconstituted antibody at 2-8°C for one month (add 0.09% Sodium Azide) or at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	glycoprotein Ib platelet alpha subunit
Database Link	Entrez Gene 2811 Human UniProt ID P07359
Background	CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. Its expression and activation seems to be regulated by VEGF and PDGF.
Synonyms	Platelet glycoprotein Ib alpha chain, Glycoprotein Ibalpha, GP-Ib alpha, GPIb-alpha
Reference Data

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