CD24 Mouse Monoclonal Antibody [Clone ID: ALB9]

Specifications

Product Data
Clone Name	ALB9
Applications	FC, IHC
Recommend Dilution	Flow Cytometry: 2 µg/5x10e5cells/test. Immunohistochemistry on frozen sections or cell smears (1:25-1:50 dilution). Studies of peripheral blood B cells.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human bone marrow malignant cells from a non-B, non-T acute leukemia
Specificity	This antibody recongnizes CD24. The molecular weight of the recognized antigen is 35-45 kDa. Recognizes B cells from pre-B to mature-B stage. The ALB9 monoclonal antibody has been assigned to the CD24 cluster of differentiation at the sixth International Workshop on Human Leucocyte Differentiation Antigens held in Kobe, Japan in 1996.
Isotype	IgG1
Formulation	PBS containing 1 mg/ml BSA as stabilizer, containing no preservatives State: Azide Free State: Lyophilized purified Ig fraction
Reconstitution Method	Restore with 1 ml of distilled water.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the reconstituted antibody at 2-8°C for one month (add 0.09% Sodium Azide) or at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	CD24 molecule
Database Link	Entrez Gene 100133941 Human UniProt ID P25063
Background	CD24 (also known as heat stable antigen) is a phosphatidylinositol linked cell surface glycoprotein with a polypeptide core of 30 amino acids and high carbohydrate content. The apparent molecular mass of the two forms of CD24 purified from a mouse lymphoma cell line appear to be in the range of 40-60 and 23-30 kDa. CD24 is expressed at all stages of B cell development and on most thymocytes. The absence of expression from mature T cells is closely associated with their maturation from CD4+ CD8+ CD24+ thymocytes to either CD4+ CD8- CD24- or CD4- CD8+ CD24- T cells. CD24 is also present on mouse granulocytes, monocytes, Langerhans cells and erythrocytes. Its ligand is P selectin (CD62P). CD24 may play a role in regulation of B cell proliferation and differentiation, and it has been proposed that heat stable antigen promotes homotypic adhesion between B lymphocytes. CD24 is also a positive marker of pancreatic cancer.
Synonyms	X62 heat stable antigen, HSA
Reference Data

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