CD56 Mouse Monoclonal Antibody [Clone ID: MEM-188]

Specifications

Product Data
Clone Name	MEM-188
Applications	FC
Recommend Dilution	Flow Cytometry analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Reactivity	Human, Primate
Host	Mouse
Clonality	Monoclonal
Immunogen	KG-1 human acute myelogenous leukemia cell line
Specificity	This antibody reacts with a 180 kDa isoform of CD56 (NCAM) expressed in leukocytes. It has been suggested that the antibody could react with rhesus monkey lymphocytes. Reactivity with other NCAM isoforms has not been tested.
Formulation	Phosphate buffered saline (PBS) Label: PerCP State: Liquid purified Ig fraction Preservative: 15 mM sodium azide
Conjugation	PerCP
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE! This products is photosensitive and should be protected from light.
Gene Name	neural cell adhesion molecule 1
Database Link	Entrez Gene 4684 Human UniProt ID P13591
Background	CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of immunoglobulin family serving as adhesive molecule which is ubiquitously expressed in nervous system, usually as 120 kDa, 140 kDa or 180 kDa isoform, and it is also found on T cells and NK cells. Polysialic modification results in reduction of CD56-mediated cell adhesion and is involved in cell migration, axonal growth, pathfinding and synaptic plasticity. CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumours and ovarian granulosa cell tumours.
Synonyms	NCAM-1, N-CAM-1, NCAM
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs), Prion diseases

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