Synaptophysin (SYP) Mouse Monoclonal Antibody [Clone ID: SY38]

Specifications

Product Data
Clone Name	SY38
Applications	IF, IHC, WB
Recommend Dilution	Immunoblotting. Immunofluorescence. Cytological Material. Immunohistochemistry on Frozen and Paraffin Sections: 1/50 with PBS, pH 7.4 (In no case Protease Pretreatment).  Incubation Time: 1 h at RT; extended with Paraffin.
Reactivity	Bovine, Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Synaptophysin from presynaptic vesicles, prepared from bovine brain.
Specificity	SY38 represents an excellent Marker for several neuroendocrine, neuronal and adrenal tumors. Neuronal and adrenal tumors such as pheochromocytomas, paragangliomas, neuroblastomas, ganglioneuroblastomas. Neuroendocrine tumors of epithelial origin: Pancreatic islet cell carcinoma, bronchial and gastrointestinal carcinoids, medullary carcinoma of thyroid. Polypeptide Reacting: Mr 38 000 transmembrane glycoprotein of presynaptic vesicles. Reactivity on Cultured Cell Lines: Rat PC-12 cell line.
Formulation	Final Solution contains PBS, pH 7.4 with 0.09% Sodium Azide as preservative and 0.5% BSA as stabilizer State: Purified State: Lyophilized purified IgG fraction
Reconstitution Method	Restore in 1 ml distilled water.
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at 2-8°C. Following reconstitution store undiluted at 2-8°C for one month  or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	synaptophysin
Database Link	Entrez Gene 6855 Human UniProt ID P08247
Background	Synaptophysin is a glycoprotein present in the membrane of neuronal presynaptic vesicles in brain, spinal cord, retina, vesicles of adrenal medulla, neuromuscular junctions, and endocrine cells. It is also expressed by neuroendocrine cells throughout the body, both normal and neoplastic. Synaptophysin is a useful marker for the identification of normal neuroendocrine cells and neuroendocrine neoplasms. This antibody reacts with neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary gland, thyroid, lung, pancreas, and gastointestinal mucosa. It also reacts with a wide spectrum of neuroendocrine neoplasms of neural type including neuroblastomas, ganglioneuroblastomas, ganglioneuromas, pheochromocytomas, chromaffin, and non chromaffin paragangliomas.
Synonyms	Neuroendocrine Marker
Reference Data

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