HDAC6 Mouse Monoclonal Antibody [Clone ID: OTI4C5]

Specifications

Product Data
Clone Name	OTI4C5
Applications	FC, IF, IHC, Simple Western, WB
Recommend Dilution	WB 1:1000~2000, IF 1:100, FLOW 1:100, IHC 1:150 ; Simple Western 1:20-1:50
Reactivity	Human, Dog, Rat, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human HDAC6 (NP_006035) produced in HEK293T cell.
Isotype	IgG1
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	131.2 kDa
Gene Name	histone deacetylase 6
Database Link	NP_006035 Entrez Gene 84581 RatEntrez Gene 480907 DogEntrez Gene 711363 MonkeyEntrez Gene 10013 Human UniProt ID Q9UBN7
Background	Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq]
Synonyms	CPBHM; HD6; JM21; PPP1R90
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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