LAMP3 Rat Monoclonal Antibody [Clone ID: 1010E1.01]

Specifications

Product Data
Clone Name	1010E1.01
Applications	FC, IF
Recommend Dilution	Intra Flow cytometry, IF
Reactivity	Canine, Feline, Human, Mouse, Sheep
Host	Rat
Clonality	Monoclonal
Immunogen	recombinant murine DC LAMP
Specificity	murine DC-LAMP (epitope in intracytoplasmic domain). Species cross-reactivity: human, cat, dog, sheep, mouse
Isotype	IgG2a
Formulation	PBS 50% glycerol Label: Alexa Fluor 488
Concentration	lot specific
Purification	QMA Hyper D ion exchange chromatography
Conjugation	Alexa Fluor 488
Storage Condition	-20°C. KEEP CONTENTS STERILE: no preservative. Coupled antibodies: glycerol protects from freezing.
Gene Name	lysosomal associated membrane protein 3
Database Link	Entrez Gene 27074 Human UniProt ID Q9UQV4
Background	The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (due to extensive glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, DC-LAMP is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DC and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface. (de Saint-Vis B et al, 1998 ; Immunity ; 9: 325-336 ; Salaun B et al, 2003 ; Eur. J. Immunol., 33 :9, 2619- 29 ; Salaun B et al, 2004 ; Am. J. Pathol., 164 :3, 861-71)
Synonyms	DCLAMP, DC-LAMP, TSC403, Dendritic Cell Marker
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.