LAMP3 Rat Monoclonal Antibody [Clone ID: 1010E1.01]

Specifications

Product Data
Clone Name	1010E1.01
Applications	IHC
Recommend Dilution	IHC paraffin (formol, Bouin) in human
Reactivity	Canine, Feline, Human, Mouse, Sheep
Host	Rat
Clonality	Monoclonal
Immunogen	recombinant murine DC LAMP
Specificity	murine DC-LAMP (epitope in intracytoplasmic domain). Species cross-reactivity: human, cat, dog, sheep, mouse.
Isotype	IgG2a
Formulation	Tris-NaCl pH 8 State: Purified
Concentration	lot specific
Purification	QMA Hyper D ion exchange chromatography
Conjugation	Unconjugated
Storage Condition	-20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles.
Gene Name	lysosomal associated membrane protein 3
Database Link	Entrez Gene 27074 Human UniProt ID Q9UQV4
Background	The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (due to extensive glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, DC-LAMP is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DC and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface. (de Saint-Vis B et al, 1998 ; Immunity ; 9: 325-336 ; Salaun B et al, 2003 ; Eur. J. Immunol., 33 :9, 2619- 29 ; Salaun B et al, 2004 ; Am. J. Pathol., 164 :3, 861-71)
Synonyms	DCLAMP, DC-LAMP, TSC403, Dendritic Cell Marker
Reference Data

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