HLA-alpha1 Mouse Monoclonal Antibody [Clone ID: mAb90]

Specifications

Product Data
Clone Name	mAb90
Applications	ELISA, FC, FN
Recommend Dilution	FACS, cell culture, ELISA capture (detecting antibody DDX0270). Usage recommendation: *This monoclonal antibody may be used between 1-20 μg/ml. *Optimal dilution should be determined by each laboratory for each application. *Coupled antibody: to maintain RT before use.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Tonsillar B cells.
Isotype	IgG1
Formulation	Purified: 100 μg in 200 μl / 50 μg in 100 μl Tris-NaCl pH 8 State: Purified
Concentration	lot specific
Purification	QMA Hyper D ion exchange chromatography.
Conjugation	Unconjugated
Storage Condition	-20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing.
Background	Antibodies to HLA class I α1 domain trigger apoptosis of activated T-cells and also control the growth/survival of human B lymphocytes. Addition of mAb 90 strongly inhibits the proliferation of CD40- activated total tonsillar B cells, purified naive, germinal center and memory B-cell subsets. mAb 90 binds to an epitope of the α-1 domain of HLA class I heavy chain induces apoptotic cell death of activated but not resting peripheral T lymphocytes. (Genestier L. et al., 1997 Blood, 90, 726-35; Genestier L. et al. 1997, Blood, 90, 3629-3639).
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.