MMP12 Mouse Monoclonal Antibody [Clone ID: 703D10]

CAT#: DDX0283P-100

MMP12 mouse monoclonal antibody, clone 703D10



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CNY 4,988.00


货期*
4周

规格
    • 100 ug

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Specifications

Product Data
Clone Name 703D10
Applications ELISA, FC, IHC
Recommend Dilution IHC and Elisa in human, intracellular flow cytometry in dog
Reactivity Canine, Human
Host Mouse
Clonality Monoclonal
Immunogen Human recombinant HME-MMP12 produced in eukaryotic cells.
Specificity Human HME-MMP12.
Species cross-reactivity: Dog.
Formulation 100 μg in 200 μl / 50 μg in 100 μl tris-NaCl pH8
State: Purified
Concentration lot specific
Purification QMA Hyper D ion exchange chromatography
Conjugation Unconjugated
Storage Condition -20°C. KEEP CONTENTS STERILE: no preservative.
Purified antibodies: avoid repeated freeze/thaw cycles.
Coupled antibodies: glycerol protects from freezing.
Gene Name matrix metallopeptidase 12
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes. HME/MMP-12, also called metalloelastase, is reported only in few cells, including tissue macrophages and hypertrophic chondrocytes. MMP-12 is critical for invasion and destruction in pathologies such as aneurysm and emphysema. The predicted molecular mass of the HME proenzyme is 54 kDa. HME mRNA and protein were detected in human alveolar macrophages. Similar to murine macrophage metalloelastase, HME readily undergoes NH2- and COOH-terminal processing to a mature 22 kDa form. Both recombinant expressed in Escherichia Coli and native HME derived from human alveolar macrophageconditioned media degraded insoluble elastin. HME is a unique human metalloproteinase that displays elastolytic activity and is expressed in alveolar macrophages; MMP-12 mediates smoke-induced inflammation by releasing TNFα from macrophages, with subsequent endothelial activation, neutrophil influx, and proteolytic matrix breakdown caused by neutrophil-derived proteases. (Demedts IK et al, 2006; Thorax, 61:196-201).
Synonyms Macrophage metalloelastase, HME, ME, Matrix metalloproteinase-12, MMP12, Macrophage elastase
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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