Myosin-1 / MYH1 Mouse Monoclonal Antibody [Clone ID: MY-32]

Specifications

Product Data
Clone Name	MY-32
Applications	IHC
Recommend Dilution	Immunohistochemistry on Paraffin Embedded Sections: Use at 1/25-1/50 in an ABC method (30 minutes at room temperature). Recommended Positive Control: Skeletal muscle.
Reactivity	Bovine, Chicken, Guinea Pig, Human, Mouse, Rabbit, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Rabbit Muscle Myosin.
Specificity	This antibody recognizes heavy chain of Human skeletal Myosin. It does not stain cardiac or smooth muscle Myosin. This antibody stains the fast twitch (type II) isomyosin molecule. Cellular Localization: Cytoplasmic.
Isotype	IgG1
Formulation	State: Ascites State: Liquid diluted Ascites Preservative: Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C.
Database Link	UniProt ID P02562
Background	Myosin is a 480kDa protein known to interact with actin in muscle and in non-muscle cells. It contains two identical heavy chains (200kDa each) and four light chains (15-26kDa). Myosin molecules consist of two major regions: tails (rod) and heads; they aggregate into filaments through the tail region and interact with actin and with ATP through the head region. Multiple forms of myosin heavy chains exist for each muscle type-skeletal, cardiac, smooth and non-muscle isomyosin forms exist in different types of skeletal muscle, depending on the physiological function of the muscle. These are designated at type I (slow-twitch) and type II (fast-twitch).
Synonyms	Myosin heavy chain 1, Myosin heavy chain skeletal muscle
Reference Data

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