Eng Rat Monoclonal Antibody [Clone ID: MJ7/18]

Specifications

Product Data
Clone Name	MJ7/18
Applications	FC
Recommend Dilution	Flow cytometry.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	Inflamed mouse skin
Specificity	This antibody reacts with CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow.
Isotype	IgG2a
Formulation	Phosphate buffered saline (PBS) Label: PE State: Liquid purified Ig fraction Preservative: 15 mM sodium azide, approx. pH 7.4 Label: Conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Concentration	lot specific
Conjugation	PE
Storage Condition	Store the antibody at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	endoglin
Database Link	Entrez Gene 13805 Mouse UniProt ID Q63961
Background	CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
Synonyms	ENG, END, HHT1, ORW, ORW1
Reference Data

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