PROX1 (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Suitable for Western Blot and Immunohistochemistry on Frozen and Paraffin Sections.
Reactivity	Fish, Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide corresponding to the Homeobox domain of Prox1.
Specificity	This antibody is reactive with Prox-1. It will be a useful tool to study lymphatic vessel density in and around human tumors. It will detect Prox-1 in the nucleus of lymphatic endothelial cells.
Formulation	State: Purified State: Liquid purified IgG fraction in PBS
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	prospero homeobox 1
Database Link	Entrez Gene 19130 MouseEntrez Gene 305066 RatEntrez Gene 5629 Human UniProt ID Q92786
Background	The homeobox gene Prox-1 was originally cloned by homology to the Drosophila melanogaster gene prospero. Prox-1 is expressed in a subpopulation of endothelial cells which by budding and sprouting, give rise to the lymphatic system. Prox-1-deficient homozygous mice have unaffected vasculogenesis and angiogenesis, but liver and lymphatics do not develop. Human Prox-1 gene has been mapped to chromosome 1q32.2-q32.3, and its product shows 94% similarity to the chicken protein. The conserved structure and expression pattern of the Prox-1 gene imply that it may play the same roles in humans as in other vertebrates. The human Prox-1 gene is most actively expressed in the developing lens. Anti-Prox-1 antibodies provide a highly specific marker of lymphatic endothelial cells.
Synonyms	PROX1
Reference Data
Protein Families	Embryonic stem cells, ES Cell Differentiation/IPS

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