CD11a / ITGAL Rat Monoclonal Antibody [Clone ID: I21/7]

Specifications

Product Data
Clone Name	I21/7
Applications	FC, IP
Recommend Dilution	Flow Cytometry. Immunoprecipitation.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	Whole BW5147 cells.
Specificity	This antibody recognises CD11a. Clone I21/7 is reported to block the cytolytic activity of cytotoxic T cell lines). We recommend the use of SM013LE for this purpose.
Isotype	IgG2a
Formulation	PBS, pH 7.4 containing 0.09% Sodium Azide as preservative. State: Purified State: Liquid purified IgG fraction.
Concentration	lot specific
Purification	Affinity Chromatography on Protein G.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Database Link	UniProt ID P24063
Background	CD11a is a 170 - 180kD type I membrane glycoprotein, which is also known as the integrin alphaL subunit. CD11a is a member of the intergrin family of adhesion molecules. The CD11a molecule is expressed on all leucocytes and associates with CD18 to form a heterodimer at the cell surface. The CD11a/CD18 heterodimer binds to intercellular adhesion molecules (ICAM); ICAM-1, ICAM-2 and ICAM-3 and is involved in cell-cell adhesion processes.
Synonyms	Integrin alpha-L, LFA1, LFA-1
Reference Data

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