CD42b / GPIbA Mouse Monoclonal Antibody [Clone ID: AK2]

Specifications

Product Data
Clone Name	AK2
Applications	FC
Recommend Dilution	Flow Cytometry: Use 10 µl of 1/50-1/100 diluted CD42b antibody tolabel 100 µl whole blood.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody recognises the Human CD42b cell surface antigen, also known as platelet glycoprotein GP1B. CD42b is expressed by platelets and megakaryocytes. Clone AK2 has been reported to block the binding of von Willebrand Factor (VWF) to platelets. We recommend the use of SM1105A for this purpose.
Formulation	PBS, pH 7.4 containing 0.09% Sodium Azide as preservative. State: Purified State: Liquid purified IgG fraction.
Concentration	lot specific
Purification	Affinity Chromatography on Protein G.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	glycoprotein Ib platelet alpha subunit
Database Link	Entrez Gene 2811 Human UniProt ID P07359
Background	CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. Its expression and activation seems to be regulated by VEGF and PDGF.
Synonyms	Platelet glycoprotein Ib alpha chain, Glycoprotein Ibalpha, GP-Ib alpha, GPIb-alpha
Reference Data

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