CD41 (ITGA2B) Mouse Monoclonal Antibody [Clone ID: MEM-06]

Specifications

Product Data
Clone Name	MEM-06
Applications	FC
Recommend Dilution	Flow cytometry: Recommended dilution: 1-5 μg/ml.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Leukocytes of patient suffering from LGL-type leukaemia
Specificity	The antibody reacts with CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIba (heavy chain; 120 kDa) and GPIIbb (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
Isotype	IgG1
Formulation	Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 State: Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography; purity: > 95% (by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	integrin subunit alpha 2b
Database Link	Entrez Gene 3674 Human UniProt ID P08514
Background	CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, a and 23 kDa b, b) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.
Synonyms	Integrin alpha-IIb, GP2B, ITGAB, GPalpha IIb
Reference Data

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