CD41-CD61 Complex Mouse Monoclonal Antibody [Clone ID: IVA30]

Specifications

Product Data
Clone Name	IVA30
Applications	ELISA, FC, IHC, IP
Recommend Dilution	Flow Cytometry. Immunoprecipitation. Immunohistochemistry on Frozen Sections. ELISA.
Reactivity	Bovine
Host	Mouse
Clonality	Monoclonal
Immunogen	Bovine trombocytes
Specificity	The antibody reacts with CD41/CD61 complex (bovine), one of the earliest markers of the megakaryocytic lineage.
Isotype	IgG2
Formulation	Phosphate buffered saline (PBS) with 15 mM Sodium Azide as preservative, approx. pH 7.4. State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
Concentration	lot specific
Purification	Affinity Chromatography on Protein A .
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	CD41 is a transmembrane glycoprotein (integrin family) composed of two chains GPIIba (heavy chain; 120 kDa) and GPIIbb (light chain; 23 kDa). CD61 non-covalently associates with CD41. CD41/CD61 complex acts as the receptor for fibrinogen, fibronectin, Von Willebrand factor, vitronectin, thrombin and mediates platelets aggregation. CD41/CD61 is expressed only by platelets and megakaryocytes; the complex may be absent or strongly reduced in Glanzmann's thrombasthenia (GT).
Synonyms	GPIIb-IIIa, ITGA2B, GP2B, ITGAB, Platelet membrane glycoprotein IIb, GPalpha IIb, GPIIb, GP3A, CD41, CD61, Integrin alpha-IIb, Integrin beta-3, ITGB3
Reference Data

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