CD42b / GPIbA Mouse Monoclonal Antibody [Clone ID: HIP1]

Specifications

Product Data
Clone Name	HIP1
Applications	FC, FN, IHC
Recommend Dilution	Flow Cytometry. Immunohistochemistry on Frozen Sections. Functional Application: The antibody inhibits the ristocetin-dependent binding of von Willebrand Factor (vWF) to platelets and ristocetin-induced platelet agglutination.
Reactivity	Human, Primate
Host	Mouse
Clonality	Monoclonal
Immunogen	Peripheral blood mononuclear cells of a patient suffering with CLL
Specificity	CD42b antibody reacts with CD42b (GPIba), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIbb) are composed in a disulfide linked heterodimer (CD42b/c; 160 kDa); CD42b/c forms a noncovalent complex with CD42a and CD42d.
Isotype	IgG1
Formulation	Phosphate buffered saline (PBS) with 15 mM Sodium Azide as preservative, approx. pH 7.4 State: Purified State: Liquid purified Ig fraction (> 95% by SDS-PAGE).
Concentration	lot specific
Purification	Protein A Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	glycoprotein Ib platelet alpha subunit
Database Link	Entrez Gene 2811 Human UniProt ID P07359
Background	CD42b (GPIba) composes together with GPIbb, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.
Synonyms	Platelet glycoprotein Ib alpha chain, Glycoprotein Ibalpha, GP-Ib alpha, GPIb-alpha
Reference Data

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