MHC Class I (monomorphic) Mouse Monoclonal Antibody [Clone ID: CVS22]

Specifications

Product Data
Clone Name	CVS22
Applications	FC, IHC, IP
Recommend Dilution	Flow cytometry: 1/25-1/200, use 10µl of this working dilution to label 10e6 cells in 100µl. Immunohistochemistry on frozen sections. Immunoprecipitation.
Reactivity	Equine
Host	Mouse
Clonality	Monoclonal
Immunogen	Equine leucocytes
Specificity	All tissues
Isotype	IgG2a
Formulation	PBS containing 0.09% Sodium azide State: Purified State: Liquid purified IgG
Concentration	lot specific
Purification	Affinity chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	MHC Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. MHC class I antigens are heterodimers consisting of one alpha chain (44kDa) with beta 2 microglobulin (11.5 kDa). The antigen is expressed by all somatic cells at varying levels. MHC Class I molecules are expressed on most nucleated cells where they present endogenously synthesized antigenic peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. Fibroblasts or neurons however only show a low level of antigen.
Synonyms	MHC Class 1, HLA Class 1
Reference Data

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