CD8A Mouse Monoclonal Antibody [Clone ID: CT6]

Specifications

Product Data
Clone Name	CT6
Applications	FC, IHC
Recommend Dilution	Immunohistochemistry on Frozen Sections: 1/100. Flow Cytometry: Use 10 µl of 1/100 diluted antibody to label 10e6 lymphocytes in 100 µl.
Reactivity	Guinea Pig
Host	Mouse
Clonality	Monoclonal
Immunogen	Peritoneal T-cells.
Specificity	Mouse anti Guinea Pig CD8 antibody, clone CT6 reacts with guinea pig CD8 present on cytotoxic T-cells. CD 8 comprises 2 subunits, alpha and beta and exists as either an alpha/alpha homodimer or an alpha/beta heterodimer. Sequence suggests that guinea pig CD8 is more closely related to human than rat or mouse CD8 (Nagarajan et al. 2004)
Isotype	IgG1
Formulation	State: Supernatant State: Concentrated Tissue Culture Supernatant with 0.09% Sodium Azide and 0.7% BSA
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	CD8a molecule
Database Link	Entrez Gene 925 Human UniProt ID P01732
Background	The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.
Synonyms	CD8 alpha chain, CD8A, MAL
Reference Data
Protein Families	Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane
Protein Pathways	Antigen processing and presentation, Cell adhesion molecules (CAMs), Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway

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