PPM1A Mouse Monoclonal Antibody [Clone ID: P6C7]

Specifications

Product Data
Clone Name	P6C7
Applications	ELISA, ICC/IF, IF, IHC, WB
Recommend Dilution	ELISA. Western blot: 1/250~1/1000 (1/250 as starting dilution). Immunofluorescence/Immnunocytochemistry. Immunohistochemistry on Paraffin Sections: 15 µg/ml.
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human PP2Calpha (1-382aa) purified from E. coli
Specificity	This antibody detects Protein Phosphatase 2C alpha (PP2C alpha).
Isotype	IgG2b, kappa
Formulation	Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Concentration	1mg/ml (determined by BCA assay)
Purification	By protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles.
Gene Name	protein phosphatase, Mg2+/Mn2+ dependent 1A
Database Link	NP_066283 Entrez Gene 5494 Human UniProt ID P35813
Background	Protein phosphatase 2C (PP2Calpha) is a Mn2+ - or Mg 2+ -dependent protein serine/threonine phosphatase that inhibits the human stress-responsive p38 and JNk MAPk pathways and regulates cellular stress response in eukaryotes. The PPM (metal-dependent protein phosphatase) family of Ser/Thr protein phosphatases have recently been shown to down-regulate the stress response pathways in eukaryotes. Within the stress pathway, key signaling kinases, which are activated by protein phosphorylation, have been proposed as the in vivo substrates of PP2Calpha, the prototypical member of the PPM family.
Synonyms	Pyruvate dehydrogenase phosphatase catalytic subunit 1, Pyruvate dehydrogenase acetyl-transferring-phosphatase 1, Protein phosphatase Mg2+/Mn2+dependent 1A, Protein phosphatase 2C, Protein phosphatase 1A (formerly 2C) magnesium-dependent alpha isoform, Protein phosphatase 1A (formerly 2C), PPM2C, PPM1A, PP2CA, PP2C alpha, PDPC 1, PDP 1, PDP, MGC9201, FLJ42306, EC 3.1.3.43
Reference Data

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