Endo G (ENDOG) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: 1 µg/ml - 2 µg/ml; this antibody detects a band of approximately 35kDa in HepG2 and 3T3 cell lysates. Immunohistochemistry on paraffin sections: 15 µg/ml; Sodium citrate buffer pH6.0 is recommended for this purpose. Recommended Positive Control: Human pancreas.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to amino acids 55 - 70 of endonuclease G.
Specificity	This antibody recognises endonuclease G (endoG).
Formulation	PBS containing 0.09% Sodium Azide State: Purified State: Liquid purified IgG
Concentration	lot specific
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	endonuclease G
Database Link	Entrez Gene 2021 Human UniProt ID Q14249
Background	Endonuclease G is a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. endoG is reported to act independently of caspases and may represent a caspase independent apoptotic pathway initiated from the mitochondria.
Synonyms	ENDOG
Reference Data

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