HSP27 (HSPB1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, WB
Recommend Dilution	Western Blot: 0.5-1.0 ug/ml, Immunocytochemistry/ Immunofluorescence: 1:50 - 1:150
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide made to an internal region of the human Crystallin AB protein (within residues 100-175). [Swiss-Prot P02511]
Isotype	IgG
Formulation	Tris-citrate/phosphate (pH 7-8) and 0.1% sodium azide
Concentration	lot specific
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	heat shock protein family B (small) member 1
Database Link	NP_001531 Entrez Gene 15507 MouseEntrez Gene 3315 Human UniProt ID P04792
Background	Crystallin AB (CryAB) is a developmentally regulated small heat shock protein known to protect cells from stress damage. It may also play an important role in the Golgi reorganization during cell division. CryAB is known to be associated with a number of neurodegenerative pathologies such as Alzheimer disease amd multiple sclerosis. As well, it has been found to be expressed in breast tumors of patients with shorter survival, suggesting that it may be a useful marker in identifying aggressive breast cancer.
Synonyms	CMT2F; HEL-S-102; HMN2B; HS.76067; Hsp25; HSP27; HSP28; SRP27
Reference Data
Protein Pathways	MAPK signaling pathway, VEGF signaling pathway

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