Stromal interaction molecule 1 (STIM1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, WB
Recommend Dilution	Immunocytochemistry/ Immunofluorescence: 1:50-1:200, Western Blot: 1:1000, Knockdown Validated: 1:1000
Reactivity	Human, Mouse, Rat, Bovine, Dog
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide made to a C-terminal region (within residues 600-685) of the human protein. [Uniprot# Q13586]
Isotype	IgG
Formulation	PBS + 30% glycerol and 0.1% sodium azide
Concentration	lot specific
Purification	peptide affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	stromal interaction molecule 1
Database Link	NP_003147 Entrez Gene 20866 MouseEntrez Gene 361618 RatEntrez Gene 608643 DogEntrez Gene 6786 Human UniProt ID Q13586
Background	Stromal interaction molecule 1 plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores. It acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, it translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit.
Synonyms	D11S4896E; GOK; IMD10; STRMK; TAM; TAM1
Reference Data
Protein Families	Transmembrane

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