PGP9.5 (UCHL1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, ICC/IF, IHC, Simple Western, WB
Recommend Dilution	Flow Cytometry: 2-5 ug/million cells/ml, Simple Western: 1:2000, Immunohistochemistry-Frozen, Western Blot: 2 ug/mL, Immunocytochemistry/ Immunofluorescence: 1:100 - 1:200, Immunohistochemistry: 2.5 - 5.0 ug/mL, Immunohistochemistry-Paraffin: 2.5 - 5.0 ug/mL, Knockout Validated
Reactivity	Human, Mouse, Monkey, Rat, Porcine, Horse
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide made to a C-terminal portion of the human UCHL1 protein (between residues 200-223). [UniProt# P09936]
Isotype	IgG
Formulation	Tris-glycine and 150mM NaCl and 0.05% sodium azide
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	ubiquitin C-terminal hydrolase L1
Database Link	NP_004172 Entrez Gene 22223 MouseEntrez Gene 29545 RatEntrez Gene 701579 MonkeyEntrez Gene 7345 Human UniProt ID P09936
Background	UCHL1 is a soluble cytoplasmic protein with a molecular weight of approximately 25,000 kD. It is present in neurons and in cells of the diffuse neuroendocrine system. UCHL1 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme. This enzyme is also known as PGP9.5. Because of its abundance in nerves, it has been widely used as a marker for peripheral nerve fibers.
Synonyms	HEL-117; NDGOA; PARK5; PGP 9.5; PGP9.5; PGP95; Uch-L1
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Parkinson's disease

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