BAP1 Mouse Monoclonal Antibody [Clone ID: 1G8]

Specifications

Product Data
Clone Name	1G8
Applications	FC, WB
Recommend Dilution	Western Blot: 2 ug/ml, Flow Cytometry: 1 ug per million cells
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Full-length human BAP1 protein expressed and purified from E.coli. [Uniprot# Q92560]
Formulation	Tris-glycine, 150mM NaCl and 0.05% sodium azide
Purification	protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	BRCA1 associated protein 1
Database Link	NP_004647 Entrez Gene 8314 Human UniProt ID Q92560
Background	Mutations within the BRCA1 gene, localized to chromosome 17q, are believed to account for approximately 45% of families with increased incidence of both early-onset breast cancer and ovarian cancer. The BRCA1 gene is expressed in numerous tissues, including breast and ovary, and encodes a predicted protein of 1863 amino acids. This protein contains a RING domain near the N-terminus and appears to encode a tumor suppressor. BARD1 (BRCA1-associated RING domain protein 1) and BAP1 (BRCA1-associated protein 1) have both been shown to bind to the N-terminus of BRCA1 and are potential mediators of tumor suppression. BARD1 contains an N-terminal RING domain and three tandem ankyrin repeats. The C-terminus of BARD1 contains a region with sequence homology to BRCA1, termed the BRCT domain. BAP1 is a ubiquitin hydrolase and has been shown to enhance BRCA1-mediated cell growth suppression.
Synonyms	hucep-6; HUCEP-13; UCHL2
Reference Data
Protein Families	Druggable Genome, Protease

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