Bcl2 Binding component 3 (BBC3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, WB
Recommend Dilution	Immunocytochemistry/ Immunofluorescence: 1:20-1:100, Western Blot: 2-4 ug/ml
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide made to a region within the C-terminus of the human PUMA protein sequence (between residues 150-193).
Formulation	Tris-glycine, 150 mM NaCl, 0.05% sodium azide
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	BCL2 binding component 3
Database Link	NP_055232 Entrez Gene 27113 Human UniProt ID Q96PG8
Background	A novel gene PUMA (p53 upregulated modulator of apoptosis) is a target for activation by the p53 tumor-suppressor gene. p53 functions as a transcriptional activator, and influences p53-inducible genes that play a role in the induction of apoptosis in response to p53. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.
Synonyms	JFY-1; JFY1; PUMA
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Huntington's disease, p53 signaling pathway

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