CARD11 Goat Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	ELISA: 1:32,000. WB: 1-3µg/ml.
Reactivity	Human, Mouse, Dog, Cow
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence C-QRKTIWVDEDQL, from the C Terminus of the protein sequence according to NP_115791.2.
Isotype	IgG
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	136922 Da
Gene Name	caspase recruitment domain family member 11
Database Link	NP_115791 Entrez Gene 108723 MouseEntrez Gene 489887 DogEntrez Gene 84433 Human UniProt ID Q9BXL7
Background	The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq]
Synonyms	BENTA; BIMP3; CARMA1; IMD11; PPBL
Reference Data
Protein Families	Druggable Genome
Protein Pathways	B cell receptor signaling pathway, T cell receptor signaling pathway

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