Mel18 (PCGF2) Goat Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1:16,000. WB: 1-2µg/ml.
Reactivity	Human, Dog, Cow
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence C-KMTVNGAPVPPLT, from the C Terminus of the protein sequence according to NP_009075.
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	41413 Da
Gene Name	polycomb group ring finger 2
Database Link	NP_009075 Entrez Gene 491035 DogEntrez Gene 7703 Human UniProt ID P35227
Background	The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq]
Synonyms	MEL-18; RNF110; ZNF144
Reference Data
Protein Families	Transcription Factors

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