gamma Catenin (JUP) Goat Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	ELISA: 1:32,000. WB 0.2-1µg/ml.IHC:5µg/ml
Reactivity	Human, Rat, Mouse, Dog, Pig
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence C-GLRPPYPTADHMLA, from the C Terminus of the protein sequence according to NP_002221, NP_068831.
Isotype	IgG
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	81.6 kDa
Gene Name	junction plakoglobin
Database Link	NP_002221 Entrez Gene 16480 MouseEntrez Gene 81679 RatEntrez Gene 480522 DogEntrez Gene 3728 Human UniProt ID P14923
Background	This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq]
Synonyms	ARVD12; CTNNG; DP3; DPIII; PDGB; PKGB
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Acute myeloid leukemia, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Pathways in cancer

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