TLR3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, IHC, WB
Recommend Dilution	WB: 1-2 µg/mL IHC-P: 1-2 µg/mL IHC-P/IF: 5-20 µg/mL. Antibody validated: Western Blot in human, mouse and rat samples Immunohistochemistry in mouse, and rat samples Immunofluorescence in the human and mouse samples. All other applications and species not yet tested.
Reactivity	Human, Mouse, Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Anti-TLR3 antibody (3643) was raised against a peptide corresponding to 15 amino acid synthetic peptide near the carboxy terminus of human TLR3. The immunogen is located within amino acids 780-830 of TLR3.
Isotype	IgG
Formulation	TLR3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/mL
Purification	TLR3 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	TLR3 antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Predicted Protein Size	Predicted: 104 kD Observed: 104 kD
Gene Name	toll like receptor 3
Database Link	NP_003256 Entrez Gene 142980 MouseEntrez Gene 7098 Human UniProt ID O15455
Background	TLR3 Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR3 is known to recognize viral double-stranded (ds) RNA, a molecular pattern associated with viral infection. Recently it has been shown to recognize viruses such as Influenza A and West Nile Virus and can mediate entry of at least West Nile Virus.
Synonyms	CD283; IIAE2
Note	Optimal dilutions for each application to be determined by the researcher.
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Toll-like receptor signaling pathway

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