IRF7 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 0.5 - 1 ug/mL, ICC: 5 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	IRF7 antibody was raised against a peptide corresponding to 14 amino acids near the center of human IRF7.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	interferon regulatory factor 7
Database Link	NP_001563 Entrez Gene 3665 Human UniProt ID Q92985
Background	Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling (3,4). There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.
Synonyms	IMD39; IRF-7H; IRF7A; IRF7B; IRF7C; IRF7H
Reference Data
Protein Families	Transcription Factors
Protein Pathways	Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway

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