Interferon beta (IFNB1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 5 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	IFN-beta antibody was raised against a 17 amino acid synthetic peptide from near the center of human IFN-b. The immunogen is located within amino acids 110 - 160 of IFN-beta.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Gene Name	interferon beta 1
Database Link	AAC41702 Entrez Gene 3456 Human UniProt ID P01574
Background	Type I Interferons (IFN-a/b) are produced primarily in response to viral infection by “Natural IFN-producing cells" (IPCs) as part of the host immune response and can also inhibit the development of tumors. IFN-b binding by its receptor results in the activation of the tyrosine kinases Jak1 and Tyk2 and phosphorylation of members of the STAT family of transcription factors, leading to the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-b. IFN-b is currently used clinically for treatment of tumors, infections and multiple sclerosis.
Synonyms	IFB; IFF; IFNB
Reference Data

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